If you change the direction of rotation of the engine, all will be fine, you will have an R4 engine but your gearbox (and car) will think it has a Dauphine one. just for fun let's think about it: mirror profile camshaft, and opposite cut on distributor skew gear as Pieter pointed. You should turn around the connecting rods, as the caps are cut at an angle, and also the piston pin should have the offset on the correct side. Also you will need a clutch disc for a right-hand turning engine. if you think you have finished, you are wrong. you will need opposite turning starter motor and dynamo. And water pump, too (or at least impeller). Fun?!!! I would rather opt for Lego...
Clementine, it is a matter of machine elements and gearing design, rather than tribology (I have graduated as an engineer, too). Hypoid gears have a definite cut depending of their normal direction of rotation. If you have opened both left-and right-hand turning 354s you will have noticed the "opposite" cut on their pinions. Of course a crownwheel/pinion assembly will turn backwardr, but with reduced efficiency. Some time ago, this had been a topic of discussion at an automotive magazine here in Greece, whether a car would lose power transmitted to the wheels when in reverse, and the final (theoretical) conclusion was, yes.